The Notch1 intracellular domain (N1ICD) is transported to the nucleus, and combines with the transcription inhibitor CSL [CBF1/Su(H)/Lag-1], releases the co-repressor, and recruits co-activators (i.e., p300 and MAML111) to induce the epithelial–mesenchymal transition (EMT) or cell proliferation, which affects tumor progression5. This evidence concerns the gene RBPJ and neoplasm.