In SCLC, higher CD3 expression was considered associated with better prognosis, while no or even contrary influence was shown in the condition of PD-L1 overexpression.46 47 Conversely, patients with SCLC with higher expression of PD-L1 and CD8 were found associated with better survival in the study of Sun et al. 48 Additionally, Bonanno and colleagues found that FOXP3 expression had prognostic value for OS in non-metastatic SCLC.49 FOXP3+/CD8+ T cell ratio was supposed as a negative prediction for patients’ prognosis in many cancers. This evidence concerns the gene FOXP3 and cancer.