Of interest, for the few patients who developed antibody-associated irAEs and samples taken before ICI introduction were available, the retrospective analysis revealed the presence of Ma2 or Hu antibodies before the onset of PNS in 4 cases,6,e33-e35 similarly to what it was observed in 3 cases of ICI-triggered myasthenia gravis.e36-e38. This evidence concerns the gene PNMA2 and paraneoplastic neurologic syndrome.