GRM5 and encephalitis: Encephalitis other than well-defined LE can be considered as intermediate risk phenotype if diagnostic criteria for possible autoimmune encephalitis are fulfilled and antibodies of high or intermediate risk are detected (see below and tables 1 and 2).10 This applies especially for those cases with multifocal or diffuse involvement not restricted to the limbic system, such as anti-mGluR5 (metabotropic glutamate receptor 5; associated with Hodgkin lymphoma),38 or anti-GABAAR encephalitis (gamma-aminobutyric-acid A receptor; associated with malignant thymoma in adult patients).39