Age, sex, BMI, education, race, Townsend deprivation index, alcohol consumption, smoking status, self-assessed health, fruit and vegetable consumption, oily fish consumption, salt intake, red meat consumption, use of blood pressure or cholesterol medicine, physical limitations on movement, existing medical condition (cardiovascular disease, stroke, cancer), existing diagnosis of diabetes (self-reported diagnosis or use of insulin). The gene discussed is INS; the disease is diabetes mellitus.