Notably, SGLT-2 inhibitors and GLP-1 receptor agonists, which are now acknowledged as the best novel therapies targeting both diabetes and cardiovascular risk, showed a similar magnitude of the effect in reducing MACE by 14% with a HR of 0.86 SGLT-2 inhibitors [19, 20] (though for canagliflozin was not significant [21] and by 16% that is 0.74 to 0.88 for GLP1 receptor agonists [22, 23]. This evidence concerns the gene GLP1R and diabetes mellitus.