When the GG genotype of SOX4 gene rs139085828 as a reference, the GA genotype, AA genotype, dominant model, and recessive model were all associated with an increased risk of osteoporosis (P < 0.05) and there was no significant correlation between the additive model and the risk of osteoporosis (P = 0.36). The gene discussed is SOX4; the disease is osteoporosis.