The differential expression of SCUBE3 between the tumor and adjacent normal tissues in all TCGA tumors were shown in Fig. 1a, in which SCUBE3 was overexpressed in breast cancer, but with relatively low expression in bladder urothelial carcinoma, kidney chromophobe, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, prostate adenocarcinoma, and thyroid carcinoma. Here, SCUBE3 is linked to breast cancer.