LRRK2 and Parkinson disease: LRRK2 PD patients present similar clinical features to those observed in idiopathic forms, Neuropathologically, the majority (~90%) of LRRK2-mutated cases display alpha-synuclein positive Lewy bodies (LBs) and Lewy neurites (LNs) at post-mortem, although a subset of patients demonstrate pleomorphic pathologies featuring tau deposits, TDP-43 and ubiquitin only inclusions.