A recent study also showed that immunization of mice with a recombinant human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein immunogen elicits CD4+ T cell responses to a glycopeptide epitope that provide help for induction of Env-specific antibody responses (Sun et al., 2020), suggesting that glycopeptide-targeting CD4+ T cell responses may constitute an important and under-studied component of the immune response elicited following infection or vaccination. The gene discussed is ERVW-1; the disease is infection.