Three injections of these drugs were performed, after which ICPI had to be canceled, since the patient developed hypophysitis with the formation of hypopituitarism (deficiency of TSH, FSH, LH, PRL, as well as cortisol and testosterone), insipidus and diabetes mellitus. At the same time, antibodies to β-cells of the pancreas (Ab to GAD, Ab to IA-2, Ab to ZnT-8 were tested) were negative, C-peptide 0.05 nmol/l (0.4–1.5), НbА1с 7.7%. This evidence concerns the gene PLOD1 and hypophysitis.