Clinical inflammation (severe vitritis) in 1 of 5 eyes receiving unmodified vector beginning 2 weeks after. Subclinical inflammation in 2 of 5 eyes and PR pathology by histology in 5 of 5 eyes receiving unmodified vector at 6 week terminus (see text). No clinical signs in any of 5 eyes receiving TLR9-inhibitory modified vector; subclinical inflammation or pathology absent or reduced. This evidence concerns the gene TLR9 and Hyalitis.