NFKB1 and metabolic disease: Hyperglycaemia initiates numerous changes influencing cellular metabolic disorders, including the redox equilibrium, inter alia via intensification of oxidation processes in mitochondria, an intensified NADPH oxidase [EC 1.6.3.1] activity; intensified non-enzymatic glycation of proteins, lipids, and nucleic acids; protein kinase C activation; formation of glycosaminoglycans; and activation of the nuclear transcription factor (NFKB) responsible for, inter alia, development of inflammatory reactions [25, 26].