Thus, although further work will need to examine how the STAT3 and NF-κB cooperate to promote the expression of pro-cachectic genes, we can conclude that the exacerbating effects of catecholamines on muscle wasting are limited to the inflammatory condition, such as sepsis, in which NF-κB is activated in skeletal muscle. The gene discussed is NFKB1; the disease is Sepsis.