TGFB1 and cancer: Multiplex expression analysis of 770 genes from each step in the cancer progression process including angiogenesis, ECM remodeling, EMT, and metastasis revealed that, compared with cells with restored WT β1 integrin, cells with β1D246A exhibited a reduced expression of genes associated with regulating the actin cytoskeleton TGF-β signaling, and transendothelial migration (Figure 4, A–C, and Supplemental Table 3).