GCG and Hypoglycemia: In response to elevated glucagon levels at the liver in CPEP, net HGP during insulin-induced hypoglycemia was 73% higher in CPEP over the final 90 minutes of Pd2 (Figure 4, C and D), leading to a 47% reduction in exogenous glucose required to sustain the plasma glucose at 50 mg/dL (AUC of 70 ± 25 vs. 37 ± 16 mg/kg × 90 minutes in SAL and CPEP, respectively; P = 0.06; Figure 4B inset).