In fact, and similar to what was reported for exhausted T cells (42), our results showed that KIRpos NK cells from R are characterized by increased levels of PDCD1 and LAG3 compared with their counterparts in NR or to KIRneg NK cells from R. Our masking experiments confirmed that the blocking of either PD-1 or LAG-3 increases the ability of NK cells from R to produce IFN-γ, although never reaching the levels of NK cells from NR, and to efficiently control HCMV infection in vitro. This evidence concerns the gene LAG3 and cytomegalovirus infection.