To be specific, the sensitivity of prostate cancer patients with Gleason score ≥8 (0.95 [95%CI 0.93-0.98]) was slightly higher than those with PSA<8 (0.93 [95%CI 0.90-0.97]), but in contrast, the specificity of the former was 0.79 ([95%CI 0.73-0.86]), which was significantly lower than that of the patients with Gleason score <8 (0.92 [95%CI 0.87 - 0.98]), and the difference was statistically significant (P <0.01). Here, KLK3 is linked to prostate cancer.