Glucose uptake via activation of the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt) signaling cascade involving multiple enzymes is able to reduce glucose levels in the extracellular milieu, which in turn contributes to decrease hyperglycemia. When insulin binds to the insulin receptor (IR) on the target cell surface, causing the IR a conformational change to form phospho insulin receptor (pIR) and phosphorylation of insulin receptor substrate-1 (pIRS-1). The gene discussed is INSR; the disease is Hyperglycemia.