Treatment with cisplatin increased TGF-β expression, and the conditioned media from cancer cells activated fibroblasts and increased their IL-6 production, concluding that IL-6 contribute to induce a paracrine loop that intercommunicated CAFs and NSCLS, resulting in chemoresistance (Abulaiti et al. 2013; Shintani et al. 2016). The gene discussed is TGFB1; the disease is cancer.