Moreover, oncostatin M (OSM), an IL6 cytokine family member, induced the expression of Zeb1, Snail (SNAI1), and OSM receptor (OSMR), inducing the regulation of EMT program and conferring resistance to gemcitabine, a current first-line therapy for pancreatic ductal adenocarcinoma (Smigiel et al. 2017). Here, SNAI1 is linked to pancreatic ductal adenocarcinoma.