Our finding that cytoplasmically localized C-terminally truncated SMARCB1 protein failed to induce senescence in vitro, argues against a tumor suppressor role of truncated SMARCB1 in the cytoplasm This view is further supported by the observation that cytoplasmic SMARCB1 staining per se did not affect overall survival in children with ATRT, which had not received treatment with nuclear export inhibitors. Here, SMARCB1 is linked to neoplasm.