Confirming the CNV-by-exome analysis, ddPCR analysis of Grb7 and Mien1, which are located close to Erbb2 in both mouse and human (the locus is syntenic in the two species), demonstrated similar levels of amplification in the tumours to Erbb2/Neu (Fig. S3, Table S10). Here, GRB7 is linked to neoplasm.