TCF7 and neoplasm: Given this complexity, to directly determine in which tumour type canonical WNT signalling was active, we assessed nuclear β-catenin staining and measured expression of canonical WNT target genes [Myc, Tcf7, Axin2 and Wif1] by quantitative real-time RT-PCR (qrtPCR) in AC(NST) and ASQC tumours of the BlgCre-NeuKI cohort.