SLC6A3 and attention deficit-hyperactivity disorder: We have previously uncovered that the hDAT coding variant A559V, identified in patients with ADHD, supports a channel-like mode in DAT which is associated with persistent DAT-mediated reverse transport of DA (DA leak) uncovered by AMPH blockade (Bowton et al., 2014; Mazei-Robison et al., 2008).