A growing body of evidence points to the synergistic interaction between Aβ and tau in driving neuronal loss, functional dysregulation, and glucose hypometabolism in AD (Iaccarino et al., 2017; Ittner and Götz, 2011; Pascoal et al., 2017; Pickett et al., 2019). This evidence concerns the gene MAPT and Alzheimer disease.