SESN1 and Alzheimer disease: Interestingly, apoptotic genes were also found in AD, including CASP3, CASP7, PLSCR1, CREB1, RELB, IGF2R, and DFFB. Sestrin (SESN1) is implicated in oxidative signalling, aging inhibition, and exercise mediation (Budanov et al., 2010; Kim et al., 2020; Yang et al., 2013).