GIT1 and Sepsis: To study the function of miR-122-5p in sepsis-induced heart injury, the rats were administrated with miR-122-5p antagomir or NC antagomir, followed by sepsis induction. Twelve hours after LPS treatment, miR-122-5p expression was significantly down-regulated but GIT1 was up-regulated by miR-122-5p antagomir injection (Figure 1(a,b)).