In this study, by analyzing the dataset from Gene Expression Omnibus (GEO), we demonstrated that circ_0008274 was in high expression in HCC tissues; and circ_0008274 was generated from the transcript of UDP-glucose glycoprotein glucosyltransferase 2 (UGGT2) (Figure 1(a)). Here, UGGT2 is linked to hepatocellular carcinoma.