Here we reported that miR-146a-5p expression was declined in the blood samples of asthma individuals and PAF-stimulated HSAECs; miR-146a-5p overexpression can inhibit the secretion of inflammatory cytokines in HSAECs treated by PAF, alleviate the barrier damage of epithelial cells, and effectively inhibit the apoptosis. The gene discussed is PCLAF; the disease is asthma.