Since the glymphatic CSF circulation is controlled by AQP4 and is altered in iNPH and AD [11], our results prompt to investigate the participation of KIDINS220 and SNX27-retromer in the function of this system, and in the dynamics and turnover of AQP4 and other cargos in iNPH and different hydrocephalus types, AD, and other neurodegenerative and neuropsychiatric disorders that concur with ventriculomegaly. The gene discussed is AQP4; the disease is Alzheimer disease.