Given that Kidins220 endosomal recycling to the cell surface is controlled by the SNX27-retromer complex [25], and that Snx27 genetic inactivation causes severe postnatal hydrocephalus in mice [24], we investigated whether hydrocephalus development in Kidins220 deficient animals could be associated with SNX27-retromer dysfunction. The gene discussed is KIDINS220; the disease is Hydrocephalus.