The VHL-null RCC cell lines (786-0, 769-P, A-498) showed a significant decrease in AURKA protein expression following treatment with NVP-BEZ235 (0.1 μM and 1.0 μM) (Fig. 2F) validating the data generated using an acute knockdown (siRNA) of VHL. The gene discussed is VHL; the disease is renal cell carcinoma.