Positive immunostaining with antibodies for EFEMP1, TIMP-3 and elastin, confirmed that the deposits made by RPE cells Efemp1R345W/R345W: C5+/+ and Efemp1R345W/R345W: C5-/- are similar in composition to basal laminar deposits and drusen found in AMD patients31. The gene discussed is TIMP3; the disease is age-related macular degeneration.