Interestingly, EIF3M is relevant to endometrial carcinogenesis, and the gene also has a modulation role among tumorigenesis-related genes in colon cancer24; RPS27A which has been identified as an important prognostic gene in hepatocellular carcinoma, has also been used as a critical biomarker for predicting the metastasis and development of gastric cancer25; UBR4 mediates the ubiquitylation of methionine adenosyltransferase IIa, which regulates the growth of hepatocellular cancer, and is is also involved in the prognosis of triple-negative breast cancer26. This evidence concerns the gene EIF3M and hepatocellular carcinoma.