Concerning cBCCs histopathological features (tumor thickness, tumor dimension, location, histological subtype, invasion level, ulceration, associated actinic keratosis, necrosis, tumor pigmentation, elastosis, and growth pattern), no significant differences were found according to p53 positive expression except for necrosis, which was a more frequent finding in the p53 positive cBCCs (25.5%) comparing with the negative ones (11.7%) (p = 0.036) (Table 2). Here, TP53 is linked to actinic keratosis.