Additionally, pilocarpine treatment in mice has been shown to induce changes in a large number of genes62,63, which may also play a role in the difference between the results identified in our study and those identified by Tiwari et al. Interestingly, the downregulation of Kv4.2 by miR-324-5p observed by Gross et al. was observed only during or shortly after seizure activity and therefore future studies should explore whether miR-324 targets different genes and therefore produces different effects in the hippocampus during status epilepticus compared to under non-seizure circumstances. This evidence concerns the gene KCND2 and status epilepticus.