The electrophysiological analyses undertaken here illustrated a clear hippocampal hyperexcitability with an increase in epilepsy-associated events in mice lacking Mir324. However, the networks regulating oscillatory activity in the hippocampi of these mice are evidently not severely impaired, as no significant changes were observed in the area power, peak amplitude or peak frequency in slices obtained from miR-324-null animals. This evidence concerns the gene MIR324 and epilepsy.