The number of detected spikes and IIDs per minute were both significantly increased in miR-324-null mice relative to WT control (p values = 2.8 × 10–3 and 0.021, respectively; N = 16 slices obtained from 6 mice per genotype), demonstrating that lack of Mir324 increases the overall incidence of these hyperexcitable epilepsy-related events (Fig. 4). The gene discussed is MIR324; the disease is epilepsy.