SQSTM1 and cancer: We reported previously that the obese and insulin-resistant phenotypes observed in the whole-body p62 deficiency resulted from reduced systemic EE14 that underscores the critical role of adipocyte’s p62 in sustaining β3-adrenergic signaling-induced mitochondrial function and thermogenesis in BAT16, as well as cancer-associated browning of subcutaneous WAT17.