NBR1 and obesity due to melanocortin 4 receptor deficiency: To determine whether the effect of inactivating global NBR1 on obesity could be accounted for by its potential role in adipocytes, we next generated a mouse line with the adipocyte-specific deletion of NBR1 either in WT mice (Nbr1AKO) or in mice in which p62 has been selectively inactivated in adipocytes both in WAT and BAT (Sqstm1AKO).