To determine whether the effect of inactivating global NBR1 on obesity could be accounted for by its potential role in adipocytes, we next generated a mouse line with the adipocyte-specific deletion of NBR1 either in WT mice (Nbr1AKO) or in mice in which p62 has been selectively inactivated in adipocytes both in WAT and BAT (Sqstm1AKO). Here, SQSTM1 is linked to obesity due to melanocortin 4 receptor deficiency.