Overall, 13 cancer hallmarks were significantly upregulated in the MCL cells from patient B (the non-responder), including MYC, OXPHOS, BCR, mTORC1, cell cycle, and PI3K/AKT/mTOR signaling (Fig. 2b, c and Supplementary Fig. 5b, c). The gene discussed is AKT1; the disease is mantle cell lymphoma.