CD8A and mantle cell lymphoma: We further examined the relationship between the activity of oncogenic pathways dysregulated in refractory MCL (Fig. 2b) and the abundance of CD8 T cells, and observed a strong negative correlation between the level of OXPHOS activity in MCL cells and CD8A expression as well as the proportion of CD8+ T cells in the TME (Fig. 6e), indicating that increased OXPHOS activity in MCL cells may have reprogrammed the TME, but this will require further investigation.