The upregulated genes included CCND1, STMN1 (also named oncoprotein 18, frequently expressed in high-grade lymphoma)20, MARCKS (the major protein kinase C substrate that regulates PI3K/AKT signaling)21,22, FCRLA (a tumor-associated antigen of BCL)23, FCRL2 (a prognostic marker of CLL with a strong correlation with mutated IGHV status)24, and VPREB3 (a pre-B-cell receptor (BCR) associated protein and a diagnostic marker for identifying c-MYC translocated lymphomas)25. This evidence concerns the gene VPREB3 and B-cell chronic lymphocytic leukemia.