Several members of the OSBP/ORPs family are linked to obesity-related diseases: ORP8 has previously been reported to play a key role in the development of type II diabetes mellitus (T2DM)2,3; ORP11 is suggested to be closely associated with cardiovascular disease risk factors and is expressed at a high level in visceral adipose tissue (VAT) in obese population with metabolic syndrome4; and ORP5 controls the synthesis of neutral lipid and thus regulates the lipid droplet (LD) size5. Here, OSBPL5 is linked to type 2 diabetes mellitus.