Further analysis detected that the levels of acetylated-SOD2 at K68 were substantially reduced in the mitochondrial fractions of CLL cells as compared to that in normal B-cells (Fig. 1C), suggesting that SOD2 in CLL cells is likely enzymatically highly active converting O2− into H2O2 more efficiently. The gene discussed is SOD2; the disease is B-cell chronic lymphocytic leukemia.