The reasons for the increase of unconjugated bilirubin include hemolysis of erythrocytes, inhibition of bilirubin conjugating mechanisms in the liver, and abnormal hepatic uptake unconjugated bilirubin, transfusion reaction, scarring of the liver (cirrhosis), and the Gilbert syndrome.24 As an IgG2 antibody, meplazumab can bind the CD147 on erythrocytes’ surface and form antibody–antigen complexes. The gene discussed is BSG; the disease is Cirrhosis.