Although BCR sequencing is a powerful tool for interrogating immune responses to infection and vaccination, it provides limited information about the antigen specificity of the sequenced BCRs.22,23 Therefore, we further performed LIBRA-seq (linking BCR to antigen specificity through sequencing) by featured barcode sequencing, which can match the naturally paired heavy and light chains with their specific antigens in a high-throughput manner. This evidence concerns the gene BCR and infection.