Among them, IGHV4-59/IGKV4-1, antibodies (C3P2FS) showed binding activity against SARS-CoV-2 nucleocapsid protein (NP) by ELISA (Fig. 5b), consistent with previous research that IGHV4-59/IGKV4-1 and IGHV4-39/IGKV3-20 linkage antibodies recognized SARS-CoV-2 NP.4 The usage frequency of paired BCR repertoires in HD were showed in Fig. 3c. This evidence concerns the gene BCR and Huntington disease.