IL1B and cryopyrin-associated periodic syndrome: The proportion of patients having no disease activity increased from baseline to 48 months in patients with CAPS without previous exposure to anti-IL-1 treatment (32.9% (24 of 73) to 41.4% (12 of 29)) and slightly decreased in those with previous exposure to IL-1 inhibitors (55.2% (80 of 145) to 48.9% (46 of 94); online supplemental figure S1 A, B).