In a mouse melanoma model, pretreatment with HDAC6 inhibitor Nexturastat A followed by administration of anti-PD-1 blocking antibodies significantly decreased tumor growth by causing increased infiltration of CD8 + T cells and natural killers cells as well as a reduction of pro-tumoral M2 macrophages in the tumor microenvironment [51]. Here, HDAC6 is linked to neoplasm.