Cytokines and chemokines from tumor cells such as IL-6, IL-10, TGF-beta, VEGF and CCL2 promote exclusion of cytotoxic T cells from the tumor microenvironment and recruit immunosuppressive cells such as regulatory T cells, myeloid-derived suppressor cells, tumor-associated macrophages, and tolerogenic dendritic cells. This evidence concerns the gene CCL2 and neoplasm.