Given the marginal advances in clinical outcomes for DIPG, recent efforts to improve translational research have focused on high-throughput sequencing of available cohorts of patient-derived DIPG tissue samples which resulted in discovery of new targets for therapeutic intervention, including interleukin 13 receptor subunit alpha 2 (IL13Rα2) [7]. The gene discussed is IL13RA2; the disease is diffuse intrinsic pontine glioma.