IL13RA2 and diffuse intrinsic pontine glioma: Overexpression of IL13Rα2 cell surface protein in cancerous cells and relative absence in normal tissue meets the first criteria of ADC design consideration and demonstrated internalization and degradation of both IL-13 and anti-IL13Rα2 antibody through IL13Rα2 receptor binding [5,10,11,16,33,34] meets the second criteria, suggesting an anti-IL13Rα2 ADC may be a viable therapy for DIPG.