ALKBH5 expression is also positively affected by KDM4C, which increases chromatin accessibility and promotes the recruitment of MYB and Pol II to the ALKBH5 promoter; this mechanism indicates the existence of a KDM4C-ALKBH5-AXL signaling axis in AML [76]. The gene discussed is KDM4C; the disease is acute myeloid leukemia.