The above results demonstrate that knockdown of METTL14, FTO, ALKBH5 or YTHDF2 exerts a weaker inhibitory effect on normal hematopoiesis than on leukemogenesis and that m6A RNA methylation is important in the initiation and progression of AML, suggesting that m6A regulators may be potential therapeutic targets for selective eradication of leukemia cells. This evidence concerns the gene FTO and acute myeloid leukemia.