However, a recent study has shown that the mesothelial cells lining the peritoneum remain intact but undergo senescence due to loss of adherent junction proteins (connexion 43, E-cadherin, occludens, desmoglein) that fosters invasion of cancer cells through the mesothelial lining to the sub-mesothelial matrix of the peritoneum to form secondary lesions [116, 118]. The gene discussed is CDH1; the disease is cancer.