NOS3 and hypertensive disorder: However, in the recessive model of oxidative stress (NOS3: TT + IGFBP3: AA vs NOS3: GG + GT IGFBP3: GG + AG), they had a prevalence of 77.0% hypertension (PR = 2.07; 95% CI1.78–2.42 p < 0.001).