The TT genotype of the NOS3 rs1799983 gene and the AA genotype of the IGFBP3 rs11977526 gene are associated with a higher prevalence of arterial hypertension, except for the TCF7L2; rs7903146 polymorphism, after adjusted analysis. Considering that the mechanism of action, responsible for higher blood pressure levels in women with the TT (NOS3) and AA (IGFBP3) genotypes, involves less metabolic production of NO and, consequently, an increase in oxidative stress, the results presented here suggest that these SNPs are directly related to blood pressure regulation. This evidence concerns the gene NOS3 and Hypertension.