In the dominant model of oxidative stress (NOS3: GG + IGFBP3: GG vs NOS3 GT + TT; IGFBP3: AG + AA), women had a prevalence of 34.7% hypertension (PR = 1.42; 95% CI 1.12–1.79; p = 0.003). The gene discussed is NOS3; the disease is hypertensive disorder.