Given the above, this study aimed to verify the prevalence of SNPs in the NOS3 rs1799983, IGFBP3 rs11977526, and TCF7L2 rs7903146 genes, as well as to investigate the possible association of SNPs occurrence with arterial hypertension in Afro-descendant women, in quilombola communities in the state of Alagoas, northeastern Brazil. This evidence concerns the gene NOS3 and Hypertension.