In this way, we found that a number of well-known oncogenes, including MYC and SOX9, were annotated as targets of tumor-specific SEs, while several tumor suppressor genes in LUAD, such as DLC1 and RB1, were linked to normal-specific SEs (Fig. 1d; Additional file 3: Table S2, Additional file 4: Table S3). This evidence concerns the gene RB1 and neoplasm.