NEFM transcriptional expression was downregulated in most cancers, including brain and CNS, breast, colorectal, gastric, kidney, esophageal, ovarian, head and neck, cervical cancers, and lymphoma, while NEFM transcriptional expression was upregulated in bladder, breast, kidney, lung cancer, and sarcoma (Fig. 1a). The gene discussed is NEFM; the disease is lung cancer.