Agents of ICB such as inhibitors of cytotoxic T-lymphocyte-associated antigen (CTLA-4), programmed cell death receptor1 (PD-1), and programmed cell death1 ligand1 (PD-L1) have been widely used in solid tumors, refractory cancers harboring microsatellite instability and classical Hodgkin lymphoma. Here, CD274 is linked to cancer.