Cytokine–cytokine receptor interaction, viral protein interaction with cytokine and cytokine receptor, primary immunodeficiency, hematopoietic cell lineage, chemokine signaling pathway, neuroactive ligand–receptor interaction, T cell receptor signaling pathway, natural killer cell-mediated cytotoxicity, IL-17 signaling pathway, and NF-kappa B signaling pathway were the top 10 pathways closely associated with NEFM DNA methylation based on KEGG enrichment analysis. Here, IL17A is linked to inborn error of immunity.