Bivariate correlation analyses carried out in T2DM patients (Additional file 2: Table S6) displayed that increased PAR levels associated with reduced methylation in multiple SOCS3 CpG sites (i.e. CpG 11.12, 13, 15.16, 17.18, 28) and with up-regulated SOCS3 expression. This evidence concerns the gene SOCS3 and type 2 diabetes mellitus.