High PAR T2DM patients showed elevated SOCS3 gene expression and decreased methylation levels—mostly in the CpG sites described above (i.e. CpG 10, 11.12, 15.16, 17.18, 28 and 29) and in one additional site (i.e. CpG 13) (Additional file 2: Table S5). The gene discussed is SOCS3; the disease is type 2 diabetes mellitus.