MTOR and neoplasm: It is caused by germline mutations in the folliculin (FLCN) gene, which is located on chromosome 17p11.2 and encodes a 579-amino acid protein with tumor suppressor function, and interacts with the mammalian target of rapamycin(mTOR) and adenosine monophosphate-activated protein kinase (AMPK) signaling pathways [2–5].