We previously demonstrated that GNA002 diffuses freely into the nucleus of cancer cells, where it covalently binds to Cys668 of the EZH2 field, triggering EZH2 degradation through the COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination, which relies on EZH2 to inhibit cancer growth [9]. Here, EZH2 is linked to cancer.