MDM4 and Familial prostate cancer: Generally speaking, miR-129-5p is considered to be a tumor suppressor and is down-regulated in prostate cancer (PC) [21], bladder cancer (BC) [22], etc. Wu Z et al. pointed out that the long non-coding RNA SNHG12 acts as a competing endogenous RNA to regulate MDM4 expression by competing with miR-129-5p in ccRCC [12].