GK5 and nonpapillary renal cell carcinoma: For instance, miR-182 [16], miR-30a [17] and miR-200c-3p [18] act as tumor suppressors to inhibit the progression of ccRCC by respectively targeting IGF1R, ADAM9 and SLC6A1, while miR-654 [19] and miR-543 [20] facilitate ccRCC cell proliferation and metastasis by targeting GK5 and Krüppel-like factor 6 (KLF-6), respectively.