SPN and nonpapillary renal cell carcinoma: As revealed by cell experiments, we found that SPN was up-regulated in ccRCC cells, and after SPN was overexpressed, ccRCC cell proliferation, migration and invasion were increased, cell apoptosis was decreased, and cell cycle was found to arrest in S and G2/M phases, which suggested that high expression of SPN facilitated the malignant progression of ccRCC.